Download e-book for iPad: Animal Transgenesis and Cloning by Louis-Marie Houdebine

By Louis-Marie Houdebine

ISBN-10: 0470848278

ISBN-13: 9780470848272

ISBN-10: 0470862289

ISBN-13: 9780470862285

Animal Transgenesis and Cloning is a concise, balanced advent to this dynamic topic, overlaying key matters and present options at present utilized in animal transgenesis and cloning. while delivering the reader with the necessities of the topic, from the molecular foundation of gene constitution and serve as to healing gene cloning in people, social and moral implications of this crucial zone of study also are thought of. Written in a transparent, available variety, the booklet starts off with an advent to key molecular biology concepts and specifically, considers suggestions used in particular for cloning animals and producing transgenic animals. Later chapters research the varied theoretical, technical and moral matters raised by means of cloning and transgenesis in either animals and people. Animal Transgenesis and Cloning: * Is an available, concise creation to this dynamic box * Discusses organic, technical and moral matters regarding cloning and transgenesis * offers an up to date account of the newest learn tools and functions. stories 'This is a suggestion for a publication translation in a box that's essentially of value and intensely topical. the belief of the ebook, from gene to transgenic animal, to its makes use of and abuses is sound and logical ...... it really is possible that i'd recommend (using) a booklet just like the single proposed' Dr Janet Smith, collage of Birmingham. 'Chapter one used to be a travel de strength! Very concise and admirably transparent ...... i used to be fairly inspired with the author's 2-page precis of eukaryotic gene law, that's no suggest achievment!' Dr David de Pomerai, college of Nottingham. '...... I felt that this can be a good written, topical publication. It covers loads of flooring ...... for my part the writer manages to supply a delightful volume of aspect and a good focussed remedy of every subject. i admire the common sense of the e-book, the truth that it pulls jointly the entire concerns into one readable and conceivable textual content' Dr Brendan Curran, Queen Mary, collage of London.

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Extra resources for Animal Transgenesis and Cloning

Sample text

The reconstituted embryo can thus start its development. Xenopus was cloned in this manner 40 years ago. This pioneer work was followed by other work done on lower vertebrates and invertebrates (Di Bernardino, 2001). The aim of these studies was the understanding of the mechanisms involved in cloning performed under these conditions. About 15 years ago, it appeared important to extend the cloning technique to farm animals to accelerate genetic selection as was already the case for plants. The protocol defined for Xenopus also worked in sheep and cloned lambs were obtained in this manner.

Foreign DNA is generally introduced by microinjection in mammal embryos. It is known that the integration rate of foreign DNA is low and it often occurs in non-functional regions of the genome, leading to no phenotypic effect. 7). The first transposon sequence is integrated into one or a few sites of the genome. By definition, transposons can replicate and integrate in multiple sites of the genome, generating numerous mutations. This approach is being used successfully in plants. Thousands of arabidopsis clones having insertional mutations generated by a transposon have been prepared in this way and are under study.

The region of the genome defined in this way is too large to directly identify and clone the gene of interest. Other genetic markers located in the same region must be found. These markers may be additional microsatellites but also genes. The growing knowledge of genome structure in humans and several other mammals facilitates the positioning of markers in the region of interest. Indeed, a given gene often has the same neighbouring genes in related species. This is particularly true between mammals and even vertebrates.

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Animal Transgenesis and Cloning by Louis-Marie Houdebine


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