By Gould R.F. (ed.)
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Finally, as indicated earlier, the test subject received a relatively large dose of 0-carotene-ds (73 pmol). Despite the introduction of a large dose CHAPTER 2 MATHEMATICAL MODELING IN NUTRITION 43 of tracer, we had assumed that it would not affect the mechanisms present for metabolism of the tracee (the nonlabeled p-carotene). Metabolic processes of the tracee are indicated by the FTCs, and FTCs usually change when new mechanisms (pathways) are induced to metabolize the tracee. A compartmental model that predicted the behavior of the tracer, the tracee in the presence of the tracer, and the steady state of the system under investigation simultaneously, with the same set of FTCs, is consistent with the assumption that the large dose of tracer did not affect the mechanisms for metabolism of the tracee after absorption.
Three recent developments stimulated interest in mathematical modeling. First, there is an opportunity to integrate quantitative characteristics of the dynamics of nutrient metabolism with knowledge of nutrient action mechanisms and health status. Second, it appears that some animal models do not mimic nutrient metabolism and health status of humans. Third, stable isotope tracers and reliable methods to measure minute amounts of them in human tissues have become more readily available. Stable isotopes are advantageous both because there is no radiation exposure to study subjects and the problems of disposing of radionuclides are avoided.
Gross, A. Labhart, M. B. Lipsett, T. Mann, L. T. Samuels, and J. ), Vol. 8, pp. 1-188. Springer-Verlag,New York. Jacquez, J. A. (1985). “Compartmental Analysis in Biology and Medicine,” 2nd ed. Univ. of Michigan Press, Ann Arbor. Kelley, S. , Green, J. , and Green, M. H. (1994). Plasma retinol (ROH): Main determinant of vitamin A (vit A) disposal rate (DR) in vit A-sufficient rats during negative vit A balance. FASEB J. 8, A444 (Abstr. 2569). 24 PART I VITAMIN METABOLISM Lewis, K. , Green, M. , and Underwood, B.
Agricultural Applications of Petroleum Products by Gould R.F. (ed.)