Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson PDF

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

ISBN-10: 9048158818

ISBN-13: 9789048158812

ISBN-10: 9401597219

ISBN-13: 9789401597210

This quantity is the complaints of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: easy technology and New medical purposes, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of overlaying either simple and scientific elements of prostaglandin and leukotriene examine.

At this assembly specific emphasis was once given to the capability software of the radical COX-2 inhibitors, the genetics of bronchial asthma in terms of the construction of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.

Traditionally, as has been performed in previous conferences of this sequence, a large amount of new fabric used to be offered and mentioned this 12 months, with specific consciousness given to the latest medical data.

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Extra resources for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

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Interestingly, cellular peroxidase activity does not significantly change during differentiation of the Mono Mac 6 and HL-60 cells (Figure 2). However, in Mono Mac 6 cells there is a 200- to 400-fold increase in cellular activity but only an about 3-fold increase in 5-LO protein expression by calcitriol when the cells were cultured before for 2 days in the presence ofTGFß [5]. These data suggest that cell maturation is accompanied by a strong decrease in 5-LO sensitivity against peroxidases. This process might be involved in the upregulation of cellular 5-LO activity during myeloid cell maturation.

1. Model ofthe N-terminal domain of5LO. 17 B. Samue/sson et al. ), Advances in Prostagiandin and Leukotriene Research, 17-20. © 2001 Kluwer Academic Publishers and Fondazione Giovanni Lorenzini. 18 Calcium binding to different parts of 5LO was determined. Native 5LO as well as its two putative domains: the N-terminal ß-barrel (0-128) and the C-terminal domain (120673), were expressed as GST fusion proteins in E. coli. All three fusion proteins were recovered in insoluble inc1usion bodies. 45Ca2+-overlay was performed directly on the solubilized inc1usion bodies without further protein purification, as described [1].

38 nucleus translocated to the cytosol immediately, whereas in the cells to which EGTA was added at the five-minute point, the cPLA2 remained localized around the nucleus. Then, to clarify the correlation between this calcium-responding translocation and cPLA2 activity, we measured release of FH] AA from the CHO cells with PAF stimulation. After PAF stimulation, 8% of total cell [3H] AA was extracellularly released. The release was inhibited to 2%, the same level as the control with calcium chelation at one minute.

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Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)


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